Microsoft Word - 73657036-file00.docx
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چکیده
Abbreviations: Ach, acetylcholine; Cch, carbachol; mAChR, CHO, chinese hamster ovary; COPD, chronic obstructive pulmonary disease; CRC, concentration-response curve; DMEM/F12, Dulbecco’s Modified Eagle Medium nutrient mixture F-12; DMSO, dimethylsulfoxide; DR, dose ratio; FLIPR, fluorometric imaging plate reader; hERG, human ether-a-go-go-related gene; KH, Krebs’ Henseleit; KRH, Krebs’ Ringers Henseleit; MEM, mimimum essential medium; muscarinic acetylcholine receptor; M1-M5, muscarinic subtype 1-5; ON t1/2, time to 50% of maximal relaxation; OFF t1/2, offset half-time of tension recovery; Penh, enhanced pause; USAN, United States adopted name; WHO, world health organization. JPET Fast Forward. Published on February 22, 2013 as DOI:10.1124/jpet.112.202051